DermaPhage® CA is a unique bio-active designed to target a microbial culprit, Cutibacterium acnes (formerly known as Propionibacterium acnes), flare-ups of which are associated with inflammation and blemish-prone skin. First discovered in the 1910s, methods utilizing bacteriophages to precisely target bacteria for destruction are highly specific and fast-acting. DermaPhage® CA is a potent cocktail of three lytic bacteriophages, highly specialized predators that attack C. acnes bacteria. The naturally occurring bacteriophages found in DermaPhage® CA selectively diminish the overpopulation of problematic C. acnes to restore the natural balance and health of the skin microbiome.

Pathogenic strains of C. acnes contribute to blemished skin by expressing high levels of virulence factors, such as porphyrins, that stimulate sebum production and inflammation in the skin. Extensive bioassays demonstrate that DermaPhage® CA safely and effectively controls C. acnes and associated inflammation while preserving beneficial microbes associated with a balanced, healthy skin microbiome. DermaPhage® CA potently reduces the formation of pernicious C. acnes biofilms and the production of a major inflammatory mediator (IL-8) common in irritated skin. In clinical trials, DermaPhage® CA visibly reduced the amounts of coproporphyrin III on the face, a telltale byproduct of C. acnes. By controlling the harmful C. acnes populations on the skin, DermaPhage® CA addresses microbial imbalances to achieve a significant reduction in blemished features.

Applications

• Facial and body care products
• Sprayable formula for use on bedding and linens
• Laundry detergents and additives