skin barrier protection from a biofermentation-derived oligopeptide

DermalRx® HydroSeal, produced via a biofermentation process that uses a proprietary strain of yeast, helps to fortify the skin’s natural barrier structures and restores its normal moisture retention capacity.
DermalRx® HydroSeal is a yeast-derived oligopeptide that fortifies the skin’s natural barrier structures and restores its normal moisture retention capacity. While moisturization products on the market only address the temporary effects of moisture loss, DermalRx® HydroSeal directly targets the skin’s barrier function for long-lasting moisturization restoration.
Produced via a biofermentation process featuring a proprietary Saccharomyces strain, DermalRx® HydroSeal delivers superior skin barrier and structural moisturization by rebuilding critical structural components essential to the functional integrity and permeability of the stratum corneum. DermalRx® HydroSeal is clinically demonstrated to reduce transepidermal water loss (TEWL), skin roughness, and the appearance of wrinkles while increasing overall skin hydration.

more collagen production*

reduction in TEWL**

reduction in skin roughness***

reduction in wrinkle appearance***
*in vitro, 3% DermalRx® HydroSeal
**9 hours clinical, single application of 3% DermalRx® HydroSeal
***4 week clinical, twice daily DermalRx® HydroSeal
DermalRx® HydroSeal
Product ID: R10067
Suggested Use Level: 1-3%
Water (and) Yeast Extract (and) Soy Amino Acids
Applications
- Anti-aging systems targeting improvement in skin’s barrier function and wrinkle reduction
- Products to treat damaged skin barrier after invasive topical procedures (laser, dermabrasion, etc.), and lip care formulations
- High performance moisturization products for dry, damaged skin
Last Updated: February 3, 2026


