skin barrier protection from a biofermentation-derived oligopeptide
DermalRx® HydroSeal is a yeast-derived oligopeptide that fortifies the skin’s natural barrier structures and restores its normal moisture retention capacity. While moisturization products on the market only address the temporary effects of moisture loss, DermalRx® HydroSeal directly targets the skin’s barrier function for long-lasting moisturization restoration.
Produced via a biofermentation process featuring a proprietary Saccharomyces strain, DermalRx® HydroSeal delivers superior skin barrier and structural moisturization by rebuilding critical structural components essential to the functional integrity and permeability of the stratum corneum. DermalRx® HydroSeal is clinically demonstrated to reduce transepidermal water loss (TEWL), skin roughness, and the appearance of wrinkles while increasing overall skin hydration.

Applications
- Anti-aging systems targeting improvement in skin’s barrier function and wrinkle reduction
- Soothing and calming formulations for sensitive skin
- Products to treat damaged skin barrier after invasive topical procedures (laser, dermabrasion, etc.), and lip care formulations
- High performance moisturization products for dry, damaged skin
DermalRx® HydroSeal
Product ID: R10067
Suggested Use Level: 1-3%
Water (and) Yeast Extract (and) Soy Amino Acids
Last Updated: February 3, 2026
