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Biocogent, LLC | 25 Health Sciences Dr. • Stony Brook, NY 11790 • 631.638.1300 • info@biocogent.com • product: DermalRx® HydroSeal-R

skin barrier protection from a biofermentation-derived oligopeptide

DermalRx Hydroseal R bubbles

DermalRx® HydroSeal-R, produced via a biofermentation process that uses a proprietary strain of yeast, helps to fortify the skin’s natural barrier structures and restores its normal moisture retention capacity.

DermalRx® HydroSeal-R is a yeast-derived oligopeptide that fortifies the skin’s natural barrier structures and restores its normal moisture retention capacity. While moisturization products on the market only address the temporary effects of moisture loss, DermalRx® HydroSeal-R directly targets the skin’s barrier function for long-lasting moisturization restoration.

Produced via a biofermentation process featuring a proprietary Saccharomyces strain, DermalRx® HydroSeal-R delivers superior skin barrier and structural moisturization by rebuilding critical structural components essential to the functional integrity and permeability of the stratum corneum. DermalRx® HydroSeal-R is clinically demonstrated to reduce transepidermal water loss (TEWL), skin roughness, and the appearance of wrinkles while increasing overall skin hydration.

more collagen production*

reduction in TEWL**

reduction in skin roughness***

reduction in wrinkle appearance***

*in vitro, 3% DermalRx® HydroSeal-R
**9 hours clinical, single application of 3% DermalRx® HydroSeal-R
***4 week clinical, twice daily DermalRx® HydroSeal-R

DermalRx® HydroSeal-R

Product ID: R10100

Suggested Use Level: 1 - 3%

Water (and) Saccharomyces Ferment Filtrate (and) 1,2-Hexanediol (and) Hydroxyacetophenone

Applications

  • Anti-aging systems targeting improvement in skin’s barrier function and wrinkle reduction
  • Soothing and calming formulations for sensitive skin
  • Products to treat damaged skin barrier after invasive topical procedures (laser, dermabrasion, etc.), and lip care formulations
  • High performance moisturization products for dry, damaged skin
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Last Updated: February 3, 2026