COMPELLING SCIENCE
About
Biocogent, LLC is a premier provider of high technology products and services to the personal care and cosmetic industries. Rooted in biotechnology, Biocogent utilizes pioneering technology in research, development, and manufacturing to provide innovative value-driven functional ingredients and services to its customers.
The company is strategically located in Stony Brook, New York and maintains business offices and research laboratories at the Long Island High Technology Incubator on the campus of Stony Brook University and Medical Center. This uniquely places the company in the epicenter of one of the nation’s preeminent academic and medical research universities providing access to vast professional and physical resources. Through our close working relationships with academicians and university professionals, we provide our customers with access to a continuous resource of current scientific discoveries and cutting-edge research and development.
Biocogent was founded by industry professionals with proven reputations for serving the needs of its customers. The deployment of our cumulative expertise in advanced R&D, product development, engineering, manufacturing, and testing services provides enabling technologies that distinguish our products and our customers within the industry. We continually strive to raise the bar to provide the best products, services, and customer support in the industry.
Expertise
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Cell Biology is a strategic technical resource at Biocogent. Utilizing over 100 years of cumulative expertise in skin, cell and tissue culture, and biochemistry, we have established ourselves as a leader in the understanding of therapeutic indicators for skin treatment products. Our laboratories are equipped to perform everything from standard cell and tissue model assays to custom developed unique bio-assays for specific targets and indicators.
Performance assessments include:
Anti-Aging
Matrix Production
• Stimulation of collagens, GAGs, adhesive proteins
Inhibition of Protease Production
• Tests to determine beneficial effects on levels of damaging enzymes
Inhibition of Protease Activities
• Tests for potential to directly inhibit enzymatic damage
Cell Proliferation & Metabolic Rate Measurements
• Tests of cellular renewal and rejuvenation
Anti-Cellulite
Adipocyte Lipolysis
• Tests for stimulation of fat breakdown
Matrix Production
• Stimulation of collagens, GAGs, adhesive proteins
Anti-Inflammatory
Prevention of Inflammatory Signaling
• Tests of efficacy for inhibiting production of molecules (interleukins, prostaglandins, etc.) that trigger the inflammatory response
Prevention of Inflammatory Tissue Damage
• Inhibition of protease production
• Inhibition of protease activities
• Protection of extracellular matrix
• Prevention of leukocyte recruitment
Antioxidant
Scavenging/Quenching of Oxidant Species
• Tests specific to particular oxidant species: superoxide, singlet oxygen, hydroxyl radical, hypochlorous acid
Prevention of Biological Oxidations
• Tests to demonstrate protection of biological molecules: lipids, proteins, nucleic acids
Protection of Cells vs. Oxidant Stress
• Tests of cell viability under oxidant stress and mitigation of inflammatory oxidant production
Measurement of Total Antioxidant Capacity
• A standardized measure of antioxidant activity for comparative ranking
Pigmentation
Tyrosinase Inhibition
• Estimation of pigmentation control at rate-limiting reaction step
Melanocyte Pigmentation
• Tests integrating all melanocyte functions
Melanoderm Pigmentation
• Tests integrating functions of the epidermal melanin unit
Toxicity
Cytotoxicity to Skin Cells
• Tests to assess integrity of membrane-bound organelles and mitochondrial activity as indices of cyto-static and cyto-toxic effects
