trust your cells to learn and restore
RNActivate™ W is a next-generation ingredient that brings the power of targeted RNA science directly to skincare.
Using a proprietary delivery platform paired with precision-designed antagomiRs, RNActivate™ W overcomes the longstanding obstacles that have prevented microRNA technologies from functioning effectively on the skin. This advanced system selectively inhibits the “wrinkle miRNA,” a small regulatory molecule known to suppress the production of key extracellular matrix components. By silencing this aging-associated signal, RNActivate™ W enables skin cells to naturally restore higher levels of type I collagen, elastin, fibrillin, and other critical structural proteins.
Watch video: SCC Showcase-Tackling the Delivery of Beneficial microRNAs to the Skin
Across in vitro, ex vivo, and clinical studies, RNActivate™ W has demonstrated consistent and measurable rejuvenating effects: increased firmness, elasticity, and thickness; smoother texture; and visible reductions in fine lines, crow’s feet, forehead lines, undereye lines, and nasolabial folds. The result is a transformative ingredient that strengthens the skin’s foundation, promotes renewal and supports a youthful, resilient appearance.
100% of subjects showed improvement in Skin Thickness, Elasticity and Firmness at all measured timepoints
RNActivate™ W boosted key extracellular matrix proteins in 3D human epidermis: collagen I (+11%), elastin (+40%), and fibrillin (+14%)
Fine lines and wrinkles showed progressive improvement, with measurable reductions of up to 14.75% by week 12 and visible improvement observed in 96.67% of panelists
RNActivate™ W
Product ID: R10140
Suggested Use Level: 0.5-3%
Water (and) Arginine (and) Salicylic Acid (and) Hydrogenated Lecithin (and) Tocopheryl Acetate (and) s-RNA-5
Applications
- Longevity focused formulations
- Advanced anti-aging
- Rejuvenating skin care products for neck and décolleté
- Preventive care | Age Defense products
- Night repair and restoring formulas
- Targeted treatments for under-eye lines and crow’s feet
- Clinical or dermatologist-branded skincare
- Premium face masks targeting smoothing or collagen boosting
Last Updated: February 26, 2026
Technical Highlights
Cells treated with RNActivate™ W exhibited substantially increased type I collagen-specific immunofluorescence (red) relative to the untransfected cells.
untransfected
RNActivate™ W
RNActivate™ W Expression Change
When applied topically to 3D reconstructed human epidermis (RHE), RNActivate™ W increased the relative abundance of key extracellular matrix proteins: type I collagen (COL1A1) by 11%, elastin (ELN) by 40%, and fibrillin (FBN) by 14%. These results demonstrate that targeted modulation of the specific miRNA family yields the intended downstream effects, confirming RNActivate™ W’s ability to upregulate critical ECM fiber proteins.
Proven Performance | Visible Results | Elevated Beauty
Clinically tested RNActivate™ W is a highly effective anti-wrinkle active delivering improvements across: texture, smoothness, firmness, elasticity, skin thickness, and multiple facial wrinkle types.
Skin Thickness (Ultrasound)
Highly significant and substantial increase in skin thickness throughout the study. 100% of subjects showed improvement at all measured timepoints.
Claim: Strengthens skin from within by supporting dermal density and skin structure.
Skin Elasticity (ElastiMeter™)
Highly statistically significant improvement to skin elasticity which increased throughout the study. 100% of subjects showed improvement at all measured timepoints.
Claim: Clinically proven to boost skin elasticity and bounce - restoring youthful suppleness.
Skin Firmness (Cutometer)
Highly significant and substantial increase to skin firmness starting at 4 weeks. 100% of subjects showed improvement at all measured timepoints.
Claim: Clinically proven to increase skin firmness, giving it a healthier, more resilient look.
Lines and Wrinkles - Glabella Lines
Progressive improvement to glabella lines with 14.75% improvement by 12 weeks. 96.67% of panelists improved by week 12.
Claim: Reduces the look of frown lines, restoring a calm, youthful expression.
